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Published juvenile animal studies demonstrate that the administration of anesthetic and sedation drugs, such as ATIVAN that either block NMDA receptors lorazepam or potentiate the activity of GABA during the period of rapid brain growth or synaptogenesis, results in widespread neuronal and oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis .
Based on comparisons across species, the window of vulnerability to these changes is believed to correlate with exposures in the third trimester of gestation through the first several months of life, but may extend out to approximately 3 years of In primates, exposure to 3 hours of ketamine that produced a light surgical plane of anesthesia did not increase neuronal cell loss, however, lorazepam treatment regimens of 5 hours or longer of isoflurane increased neuronal cell loss .
Data from isoflurane-treated rodents and ketamine-treated ativan vs xanax vs klonopin ativan odt expired lorazepam side effects lorazepam elderly ativan primates suggest that the neuronal and oligodendrocyte cell losses are associated with prolonged cognitive deficits in learning and memory .
The clinical significance of these nonclinical findings is not known, and healthcare providers should balance the benefits of appropriate anesthesia in pregnant women, neonates and young children who require procedures with the potential risks suggested by is lorazepam a high risk med ativan rx lorazepam review lorazepam que es lorazepam jokes lorazepam the nonclinical data .

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