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Following a dose of radiolabelled pregabalin, lyrica best dosage lyrica side effects fertility lyrica vs gralise lyrica and alcohol lyrica generic approximately 98% of the radioactivity recovered in the urine was unchanged pregabalin .
lyrica 9% of the dose . The N-methylated derivative of pregabalin, the major metabolite of pregabalin found in urine, lyrica accounted for 0 .
In preclinical studies, there was no indication of racemisation of pregabalin S-enantiomer to the lyrica R-enantiomer .
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lyrica Renal clearance (CLcr) derived from Phase I studies was 73 mL/min .
Pregabalin mean elimination lyrica half-life is 6 . lyrica 3 hours .
Pregabalin plasma clearance and renal clearance are directly proportional to lyrica creatinine clearance (see Special Populations, Renal Impairment) .
Version: pfplyric10113 Supersedes: pfplyric10611 Pregabalin clearance is reduced in patients with impaired renal function (see lyrica DOSAGE AND ADMINISTRATION, Use in Renal Impairment, Table 7) .
Linearity / Non-linearity lyrica Pregabalin pharmacokinetics are linear over the recommended daily dose range .
Inter-subject pharmacokinetic variability for pregabalin lyrica is low (<20%) .
Multiple dose pharmacokinetics are predictable from lyrica single-dose data .
Special Populations Population lyrica pharmacokinetic analyses of the Phase 2/3 studies in patients with chronic pain, general anxiety disorder (GAD) or partial seizures showed that the relationship between daily dose and pregabalin exposure is similar among Caucasians, Blacks and Hispanics .

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